Da en af præsidentens nære venner myrdes af colombianske narkosmuglere, bliver agenten Jack Ryan sat til at komme til bunds i sagen. Da en gruppe soldater bliver sendt ind i Colombia på straffeaktion og efterfølgende taget til fange, nægter præsidentens lakajer ethvert kendskab, og det bliver op til Jack at få dem ud, straffe de skyldige og oprulle en større konspiration
Based on a true story and the book, At the Devil's Table: The Untold Story of the Insider Who Brought Down the Cali Cartel by award-winning investigative reporter William C. Rempel, En la Boca del Lobo follows the series of events that ultimately lead to the dramatic downfall of Colombia’s infamous Cali drug cartel. The story centers on Ricardo Salgado, an engineer and soldier who rises ranks and became in charge of the security of the godfather of the Cali Cartel, one of the largest criminal organizations in the world and rival of the Medellin Cartel.
