When two brothers, Josh and Mike, go to a small southern town for a vacation, they find most of the residents either dead or missing. When Mike himself goes missing, Josh teams up with the local sheriff and an attractive school teacher to find him until Josh discovers that the whole town and most of it's people have been infected by a form of toxic waste, and they have all turned into toxic vampires whom prowl the streets at night for human blood!
With the accidental discovery of a lethal bio-agent at her research facility, Dr. Christine Ruben decides to double cross her own government by stealing the deadly formula to keep it out of the clutches of the military, whom she doesn't trust. To make her rendezvous with some confederates who promise to get her out of the country, she recruits daredevil driver Judd Pierson and his partner Casey Lee, who are down on their luck and take the job without knowing what they're getting into.
