Quiet, withdrawn 13-year-old Rynn Jacobs lives peacefully in her home in a New England beach town. Whenever the prying landlady inquires after Rynn's father, she politely claims that he's in the city on business. But when the landlady's creepy and increasingly persistent son, Frank, won't leave Rynn alone, she teams up with kindly neighbor boy Mario to maintain the dark family secret that she's been keeping to herself.
Remy is a medical student who has a flair for making his patients comfortable. His genuine concern for the patients in his charge marks him as a hot prospect in his internship program. Pamela works at a children's book publishing company. The two meet via Pamela's brother, who is also Remy's good friend. They fall in love and get an apartment in the East Village of New York. Soon after, the couple begins to indulge in speed and barbiturates. They become heavily addicted. Remy is thrown out of medical school and Pamela quits her job. Remy soon finds himself in debt with the local dealer, Stutter, who introduces his customer to heroin as a revenge for his late bill. Pamela faces the prospect of getting sober at her brother's clinic, but must leave behind a destitute Remy in order to do it.
