Kembali atas permintaan ramai, pasangan dinamik My Spy, ejen CIA lama, JJ dan anak tirinya, Sophie, berusia 14 tahun, yang juga anak didiknya, bersatu semula untuk menyelamatkan dunia apabila lawatan koir sekolah tinggi ke Itali tergendala akibat komplot nuklear jahat yang menyasarkan Vatican City.
After punching a famous curator in the face for criticizing his work as "textbook and lifeless," Handa Seishuu is sent to Gotō Island to calm his nerves and find new inspiration for his calligraphy. Growing up in the city all his life, though, Handa must adapt to country life while meeting an assortment of quirky people during his tenure.
